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Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we cou...

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Detalles Bibliográficos
Autores principales: Lun, Xiao-Kang, Zanotelli, Vito RT, Wade, James D, Schapiro, Denis, Tognetti, Marco, Dobberstein, Nadine, Bodenmiller, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617104/
https://www.ncbi.nlm.nih.gov/pubmed/28092656
http://dx.doi.org/10.1038/nbt.3770