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Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry
Signaling networks are key regulators of cellular function. Although the concentrations of signaling proteins are perturbed in disease states, such as cancer, and are modulated by drug therapies, our understanding of how such changes shape the properties of signaling networks is limited. Here we cou...
Autores principales: | Lun, Xiao-Kang, Zanotelli, Vito RT, Wade, James D, Schapiro, Denis, Tognetti, Marco, Dobberstein, Nadine, Bodenmiller, Bernd |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617104/ https://www.ncbi.nlm.nih.gov/pubmed/28092656 http://dx.doi.org/10.1038/nbt.3770 |
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