Chiral platinum (II)-4-(2,3-dihydroxypropyl)- formamide oxo-aporphine (FOA) complexes promote tumor cells apoptosis by directly targeting G-quadruplex DNA in vitro and in vivo

Three platinum(II) complexes, 4 (LC-004), 5 (LC-005), and 6 (LC-006), with the chiral FOA ligands R/S-(±)-FOA (1), R-(+)-FOA (2) and S-(–)-FOA (3), respectively, were synthesized and characterized. As potential anti-tumor agents, these complexes show higher cytotoxicity to BEL-7404 cells than the HL...

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Detalles Bibliográficos
Autores principales: Qin, Qi-Pin, Qin, Jiao-Lan, Chen, Ming, Li, Yu-Lan, Meng, Ting, Zhou, Jie, Liang, Hong, Chen, Zhen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617480/
https://www.ncbi.nlm.nih.gov/pubmed/28977920
http://dx.doi.org/10.18632/oncotarget.18778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617480/
https://www.ncbi.nlm.nih.gov/pubmed/28977920
http://dx.doi.org/10.18632/oncotarget.18778

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