Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer

Androgen receptor (AR) mediates initiation and progression of prostate cancer (PCa); AR-driven transcription is activated by binding of androgens to the ligand-binding domain (LBD) of AR. Androgen ablation therapy offers only a temporary relief of locally advanced and metastatic PCa, and the disease...

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Detalles Bibliográficos
Autores principales: Morozov, Viacheslav M., Li, Ying, Clowers, Matthew M., Ishov, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617492/
https://www.ncbi.nlm.nih.gov/pubmed/28977932
http://dx.doi.org/10.18632/oncotarget.19100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617492/
https://www.ncbi.nlm.nih.gov/pubmed/28977932
http://dx.doi.org/10.18632/oncotarget.19100

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