Cargando…

Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer

Androgen receptor (AR) mediates initiation and progression of prostate cancer (PCa); AR-driven transcription is activated by binding of androgens to the ligand-binding domain (LBD) of AR. Androgen ablation therapy offers only a temporary relief of locally advanced and metastatic PCa, and the disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morozov, Viacheslav M., Li, Ying, Clowers, Matthew M., Ishov, Alexander M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617492/ https://www.ncbi.nlm.nih.gov/pubmed/28977932 http://dx.doi.org/10.18632/oncotarget.19100

Ejemplares similares

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
por: Manna, Sugata, et al.
Publicado: (2015)

Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
por: Northrup, Daniel, et al.
Publicado: (2017)

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1
por: Camacho, Jessica, et al.
Publicado: (2018)

Targeting Esophageal Squamous Cell Carcinoma by Combining Copper Ionophore Disulfiram and JMJD3/UTX Inhibitor GSK J4
por: Yang, Canlin, et al.
Publicado: (2023)

The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
por: Sui, Aixia, et al.
Publicado: (2017)

The H3K27me3 demethylase UTX in normal development and disease
por: Van der Meulen, Joni, et al.
Publicado: (2014)

Somatic mutations of the histone H3K27 demethylase, UTX, in human cancer
por: van Haaften, Gijs, et al.
Publicado: (2009)

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model
por: Wang, Jing-Jing, et al.
Publicado: (2022)

H3K27 Demethylase, JMJD3, Regulates Fragmentation of Spermatogonial Cysts
por: Iwamori, Naoki, et al.
Publicado: (2013)

KSHV PAN RNA Associates with Demethylases UTX and JMJD3 to Activate Lytic Replication through a Physical Interaction with the Virus Genome
por: Rossetto, Cyprian C., et al.
Publicado: (2012)

The Functions of the Demethylase JMJD3 in Cancer
por: Sanchez, Anna, et al.
Publicado: (2021)

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
por: Cuyàs, Elisabet, et al.
Publicado: (2018)

The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
por: Ota, Kazushige, et al.
Publicado: (2017)

The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice
por: Tang, Gang-Bin, et al.
Publicado: (2017)

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
por: Li, Yunan, et al.
Publicado: (2018)

The Histone H3 Lysine 27-Specific Demethylase Jmjd3 Is Required for Neural Commitment
por: Burgold, Thomas, et al.
Publicado: (2008)

JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
por: Shan, Yongli, et al.
Publicado: (2020)

Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer
por: Sarwar, Sadia, et al.
Publicado: (2022)

Correction: The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
Publicado: (2017)

Histone H3K27 demethylase UTX compromises articular chondrocyte anabolism and aggravates osteoarthritic degeneration
por: Lian, Wei-Shiung, et al.
Publicado: (2022)

The histone H3 lysine-27 demethylase UTX plays a critical role in colorectal cancer cell proliferation
por: Tang, Xin, et al.
Publicado: (2019)

The C. elegans H3K27 Demethylase UTX-1 Is Essential for Normal Development, Independent of Its Enzymatic Activity
por: Vandamme, Julien, et al.
Publicado: (2012)

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner
por: Copur, Ömer, et al.
Publicado: (2013)

Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A
por: Fotouhi, Omid, et al.
Publicado: (2023)

Histone demethylase JMJD3 is required for osteoblast differentiation in mice
por: Zhang, Feng, et al.
Publicado: (2015)

The Roles of Histone Demethylase Jmjd3 in Osteoblast Differentiation and Apoptosis
por: Yang, Di, et al.
Publicado: (2017)

The Maternal Effect Genes UTX and JMJD3 Play Contrasting Roles in Mus musculus Preimplantation Embryo Development
por: Yang, Lei, et al.
Publicado: (2016)

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
por: Romero, Octavio A., et al.
Publicado: (2021)

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells
por: Pediconi, Natalia, et al.
Publicado: (2019)

The Prognostic Significance of Histone Demethylase UTX in Esophageal Squamous Cell Carcinoma
por: Li, Shau-Hsuan, et al.
Publicado: (2018)

Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase
por: Lee, Su-Hyun, et al.
Publicado: (2021)

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays
por: Lobo-Silva, Jessica, et al.
Publicado: (2020)

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development
por: Shpargel, Karl B., et al.
Publicado: (2012)

RNA polymerase II progression through H3K27me3-enriched gene bodies requires JMJD3 histone demethylase
por: Estarás, Conchi, et al.
Publicado: (2013)

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx
por: Morozov, Viacheslav M., et al.
Publicado: (2017)

Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis
por: Jiang, Yan, et al.
Publicado: (2021)

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
por: Sherry-Lynes, Maureen M., et al.
Publicado: (2017)

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms
por: Davis, Frank M., et al.
Publicado: (2021)

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection
por: Holla, Sahana, et al.
Publicado: (2016)

Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3
por: Xia, Ming, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_l9hs65stdp2698625dah3ocsnk