Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma. To study ACT and immunotherapies in a humanized model, we have developed PDXv2.0 — a melanoma PDX model where tumor cells and tumor-infiltrat...

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Detalles Bibliográficos
Autores principales: Jespersen, Henrik, Lindberg, Mattias F., Donia, Marco, Söderberg, Elin M. V., Andersen, Rikke, Keller, Ulrich, Ny, Lars, Svane, Inge Marie, Nilsson, Lisa M., Nilsson, Jonas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617838/
https://www.ncbi.nlm.nih.gov/pubmed/28955032
http://dx.doi.org/10.1038/s41467-017-00786-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617838/
https://www.ncbi.nlm.nih.gov/pubmed/28955032
http://dx.doi.org/10.1038/s41467-017-00786-z

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