C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation

Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely known. Moreover, reduced nephrin tyrosine phospho...

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Detalles Bibliográficos
Autores principales: Lee, Jiyoun, Koh, Ara, Jeong, Heeyoon, Kim, Eui, Ha, Tae-Sun, Saleem, Moin A., Ryu, Sung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617844/
https://www.ncbi.nlm.nih.gov/pubmed/28955049
http://dx.doi.org/10.1038/s41598-017-12382-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617844/
https://www.ncbi.nlm.nih.gov/pubmed/28955049
http://dx.doi.org/10.1038/s41598-017-12382-8

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