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Synthesis and Immunological Evaluation of Virus-Like Particle-Milbemycin A(3)/A(4) Conjugates

Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A(3)/A(4) derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a novel 17-atom-long linker containing a term...

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Detalles Bibliográficos
Autores principales: Zeltins, Andris, Turks, Māris, Skrastina, Dace, Lugiņina, Jevgeņija, Kalnciema, Ieva, Balke, Ina, Bizdēna, Ērika, Skrivelis, Vitalijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617982/
https://www.ncbi.nlm.nih.gov/pubmed/28892001
http://dx.doi.org/10.3390/antibiotics6030018