Suppression of mRNA Nanoparticle Transfection in Human Fibroblasts by Selected Interferon Inhibiting Small Molecule Compounds

In vitro transcribed (IVT) mRNA is increasingly applied in lieu of DNA to deliver reprogramming genes to fibroblasts for stem cell derivation. However, IVT mRNA induces interferon (IFN) responses from mammalian cells that reduces transfection efficiency. It has been previously suggested that small m...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Krishnan, Manoj N., Phua, Kyle K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618237/
https://www.ncbi.nlm.nih.gov/pubmed/28758979
http://dx.doi.org/10.3390/biom7030056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618237/
https://www.ncbi.nlm.nih.gov/pubmed/28758979
http://dx.doi.org/10.3390/biom7030056

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