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Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors
Hypoxia and acidosis are salient features of many tumors, leading to a completely different metabolism compared to normal cells. Two of the simplest metabolic products, protons and bicarbonate, are generated by the catalytic activity of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), with at...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618333/ https://www.ncbi.nlm.nih.gov/pubmed/28926956 http://dx.doi.org/10.3390/metabo7030048 |