A tissue-specific promoter derived from a SINE retrotransposon drives biallelic expression of PLAGL1 in human lymphocytes

The imprinted gene PLAGL1 is an important regulator of apoptosis and cell cycle arrest. Loss of its expression has been implicated in tumorigenesis in a range of different cancers, and overexpression during fetal development causes transient neonatal diabetes mellitus (TNDM). PLAGL1 lies within an i...

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Detalles Bibliográficos
Autores principales: Smith, Claire E. L., Alexandraki, Alexia, Cordery, Sarah F., Parmar, Rekha, Bonthron, David T., Valleley, Elizabeth M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619815/
https://www.ncbi.nlm.nih.gov/pubmed/28957425
http://dx.doi.org/10.1371/journal.pone.0185678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619815/
https://www.ncbi.nlm.nih.gov/pubmed/28957425
http://dx.doi.org/10.1371/journal.pone.0185678

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