Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase

The LOW-density lipoprotein related protein 6 (LRP6) receptor is an important effector of canonical Wnt signaling, a developmental pathway, whose dysregulation has been implicated in various diseases including cancer. The membrane proximal low-density lipoprotein (LDL) receptor repeats in LRP6 exhib...

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Detalles Bibliográficos
Autores principales: Vijayakumar, Sapna, Liu, Guizhong, Wen, Huei-Chi, Abu, Yaa, Chong, Robert, Nastri, Horacio, Bornstein, Gadi G., Pan, Zhen-Qiang, Aaronson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620007/
https://www.ncbi.nlm.nih.gov/pubmed/28966723
http://dx.doi.org/10.18632/genesandcancer.146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620007/
https://www.ncbi.nlm.nih.gov/pubmed/28966723
http://dx.doi.org/10.18632/genesandcancer.146

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