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Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase

The LOW-density lipoprotein related protein 6 (LRP6) receptor is an important effector of canonical Wnt signaling, a developmental pathway, whose dysregulation has been implicated in various diseases including cancer. The membrane proximal low-density lipoprotein (LDL) receptor repeats in LRP6 exhib...

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Detalles Bibliográficos
Autores principales:	Vijayakumar, Sapna, Liu, Guizhong, Wen, Huei-Chi, Abu, Yaa, Chong, Robert, Nastri, Horacio, Bornstein, Gadi G., Pan, Zhen-Qiang, Aaronson, Stuart A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620007/ https://www.ncbi.nlm.nih.gov/pubmed/28966723 http://dx.doi.org/10.18632/genesandcancer.146

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