Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis

Marked up-regulation of aldose reductase (AR) is reportedly associated with the development of hepatocellular carcinoma (HCC). We investigated how aberrantly overexpressed AR might promote oncogenic transformation in liver cells and tissues. We found that overexpressed AR interacted with the kinase...

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Detalles Bibliográficos
Autores principales: Zhao, Jia-Xing, Yuan, Ya-Wei, Cai, Cheng-Fu, Shen, Dong-Yan, Chen, Mao-Li, Ye, Feng, Mi, Yan-Jun, Luo, Qi-Cong, Cai, Wang-Yu, Zhang, Wei, Long, Ying, Zeng, Yong, Ye, Guo-Dong, Yang, Shu-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620151/
https://www.ncbi.nlm.nih.gov/pubmed/28978011
http://dx.doi.org/10.18632/oncotarget.17791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620151/
https://www.ncbi.nlm.nih.gov/pubmed/28978011
http://dx.doi.org/10.18632/oncotarget.17791

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