Aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD(+) reduction

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the aldehyde dehydrogenase superfamily that oxidizes aldehydes to their corresponding acids, reactions that are coupled to the reduction of NAD(+) to NADH. We report here that ALDH1A1 can also use glutathione (GSH) and dihydrolipoic acid (DHLA) as...

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Detalles Bibliográficos
Autores principales: Wang, Baiyun, Chen, Xue, Wang, Zixi, Xiong, Wei, Xu, Tao, Zhao, Xinyuan, Cao, Yang, Guo, Yanru, Li, Lin, Chen, She, Huang, Song, Wang, Xiaodong, Fang, Min, Shen, Zhirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620155/
https://www.ncbi.nlm.nih.gov/pubmed/28978015
http://dx.doi.org/10.18632/oncotarget.17688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620155/
https://www.ncbi.nlm.nih.gov/pubmed/28978015
http://dx.doi.org/10.18632/oncotarget.17688

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