A novel AMPK activator hernandezine inhibits LPS-induced TNFα production

Here, we found that hernandezine, a novel AMPK activator, inhibited LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). Activation of AMPK is required for hernandezine-induced anti-LPS response. AMPKα shRNA or dominant negative mutation (T172A) blocked hernandezi...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ping, Li, Xiaofang, Wu, Yonghong, Li, Manxiang, Wang, Xiaochuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620168/
https://www.ncbi.nlm.nih.gov/pubmed/28978028
http://dx.doi.org/10.18632/oncotarget.18365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620168/
https://www.ncbi.nlm.nih.gov/pubmed/28978028
http://dx.doi.org/10.18632/oncotarget.18365

Ejemplares similares