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A novel AMPK activator hernandezine inhibits LPS-induced TNFα production

Here, we found that hernandezine, a novel AMPK activator, inhibited LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). Activation of AMPK is required for hernandezine-induced anti-LPS response. AMPKα shRNA or dominant negative mutation (T172A) blocked hernandezi...

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Detalles Bibliográficos
Autores principales:	Li, Ping, Li, Xiaofang, Wu, Yonghong, Li, Manxiang, Wang, Xiaochuang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620168/ https://www.ncbi.nlm.nih.gov/pubmed/28978028 http://dx.doi.org/10.18632/oncotarget.18365

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