Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes

Vitamin D deficiency could cause insulin resistance. However, the underlying mechanisms are unclear. The 1α-Hydroxylase [“1α(OH)ase”] is a key enzyme for activate vitamin D3 synthesis. Here, we show that 1α(OH)ase stable knockdown by targeted shRNA led to vitamin D3 depletion in L02 hepatocytes. 1α(...

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Detalles Bibliográficos
Autores principales: Tao, Sha, Yuan, Qi, Mao, Li, Chen, Feng-Li, Ji, Feng, Cui, Zhao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620196/
https://www.ncbi.nlm.nih.gov/pubmed/28978056
http://dx.doi.org/10.18632/oncotarget.18754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620196/
https://www.ncbi.nlm.nih.gov/pubmed/28978056
http://dx.doi.org/10.18632/oncotarget.18754

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