Cell cycle perturbation induced by gemcitabine in human tumor cells in cell culture, xenografts and bladder cancer patients: implications for clinical trial designs combining gemcitabine with a Chk1 inhibitor

Gemcitabine irreversibly inhibits ribonucleotide reductase and induces S phase arrest but whether this occurs in tumors in mice or patients has not been established. Tumor cells in culture were incubated with gemcitabine for 6 h to approximate the administration schedule in a patient. Concentrations...

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Detalles Bibliográficos
Autores principales: Montano, Ryan, Khan, Nadeem, Hou, Huagang, Seigne, John, Ernstoff, Marc S., Lewis, Lionel D., Eastman, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620209/
https://www.ncbi.nlm.nih.gov/pubmed/28978069
http://dx.doi.org/10.18632/oncotarget.18834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620209/
https://www.ncbi.nlm.nih.gov/pubmed/28978069
http://dx.doi.org/10.18632/oncotarget.18834

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