Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development. Dormant MM cells can be reactivated after melphalan treat...

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Detalles Bibliográficos
Autores principales: Chai, Ryan C., McDonald, Michelle M., Terry, Rachael L., Kovačić, Nataša, Down, Jenny M., Pettitt, Jessica A., Mohanty, Sindhu T., Shah, Shruti, Haffari, Gholamreza, Xu, Jiake, Gillespie, Matthew T., Rogers, Michael J., Price, John T., Croucher, Peter I., Quinn, Julian M.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620235/
https://www.ncbi.nlm.nih.gov/pubmed/28978095
http://dx.doi.org/10.18632/oncotarget.19152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620235/
https://www.ncbi.nlm.nih.gov/pubmed/28978095
http://dx.doi.org/10.18632/oncotarget.19152

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