The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells

The histone methyltransferase EZH2 plays a role in maintenance of the stem component of cancer, and its overexpression and/or mutation typically drives tumor aggressiveness, drug resistance and patients’ poor prognosis. In this study, we use mouse and human medulloblastoma stem-like cells belonging...

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Detalles Bibliográficos
Autores principales: Miele, Evelina, Valente, Sergio, Alfano, Vincenzo, Silvano, Marianna, Mellini, Paolo, Borovika, Diana, Marrocco, Biagina, Po, Agnese, Besharat, Zein Mersini, Catanzaro, Giuseppina, Battaglia, Giuseppe, Abballe, Luana, Zwergel, Clemens, Stazi, Giulia, Milite, Ciro, Castellano, Sabrina, Tafani, Marco, Trapencieris, Peteris, Mai, Antonello, Ferretti, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620277/
https://www.ncbi.nlm.nih.gov/pubmed/28978137
http://dx.doi.org/10.18632/oncotarget.19782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620277/
https://www.ncbi.nlm.nih.gov/pubmed/28978137
http://dx.doi.org/10.18632/oncotarget.19782

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