PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration

Alkylating agents are commonly used to treat cancer. Although base excision repair (BER) is a major pathway for repairing DNA alkylation damage, under certain conditions, the initiation of BER produces toxic repair intermediates that damage healthy tissues. The initiation of BER by the alkyladenine...

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Detalles Bibliográficos
Autores principales: Allocca, Mariacarmela, Corrigan, Joshua J., Fake, Kimberly R., Calvo, Jennifer A., Samson, Leona D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620290/
https://www.ncbi.nlm.nih.gov/pubmed/28978150
http://dx.doi.org/10.18632/oncotarget.19844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620290/
https://www.ncbi.nlm.nih.gov/pubmed/28978150
http://dx.doi.org/10.18632/oncotarget.19844

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