Reconstituted IMPDH polymers accommodate both catalytically active and inactive conformations

Several metabolic enzymes undergo reversible polymerization into macromolecular assemblies. The function of these assemblies is often unclear, but in some cases they regulate enzyme activity and metabolic homeostasis. The guanine nucleotide biosynthetic enzyme inosine monophosphate dehydrogenase (IM...

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Detalles Bibliográficos
Autores principales: Anthony, Sajitha A., Burrell, Anika L., Johnson, Matthew C., Duong-Ly, Krisna C., Kuo, Yin-Ming, Simonet, Jacqueline C., Michener, Peter, Andrews, Andrew, Kollman, Justin M., Peterson, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620369/
https://www.ncbi.nlm.nih.gov/pubmed/28794265
http://dx.doi.org/10.1091/mbc.E17-04-0263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620369/
https://www.ncbi.nlm.nih.gov/pubmed/28794265
http://dx.doi.org/10.1091/mbc.E17-04-0263

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