Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER–Golgi intermediate compartment

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on microglia within the brain. Several rare mutations in TREM2 cause an early-onset form of neurodegeneration when inherited homozygously. Here we investigate how these mutations affect the intracellular tr...

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Detalles Bibliográficos
Autores principales: Sirkis, Daniel W., Aparicio, Renan E., Schekman, Randy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620379/
https://www.ncbi.nlm.nih.gov/pubmed/28768830
http://dx.doi.org/10.1091/mbc.E17-06-0423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620379/
https://www.ncbi.nlm.nih.gov/pubmed/28768830
http://dx.doi.org/10.1091/mbc.E17-06-0423

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