Development of RP-HPLC, Stability Indicating Method for Degradation Products of Linagliptin in Presence of Metformin HCl by Applying 2 Level Factorial Design; and Identification of Impurity-VII, VIII and IX and Synthesis of Impurity-VII

The novel reverse phase-high performance liquid chromatography (RP-HPLC), stability indicating method was developed for determination of linagliptin (LGP) and its related substances in linagliptin and metformin HCl (MET HCl) tablets by implementing design of experiment to understand the critical met...

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Detalles Bibliográficos
Autores principales: Jadhav, Sushant B., Reddy, P. Sunil, Narayanan, Kalyanaraman L., Bhosale, Popatrao N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620513/
https://www.ncbi.nlm.nih.gov/pubmed/28653975
http://dx.doi.org/10.3390/scipharm85030025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620513/
https://www.ncbi.nlm.nih.gov/pubmed/28653975
http://dx.doi.org/10.3390/scipharm85030025

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