Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

Halogenation plays a significant role in the activity of the glycopeptide antibiotics (GPAs), although up until now the timing and therefore exact substrate involved was unclear. Here, we present results combined from in vivo and in vitro studies that reveal the substrates for the halogenase enzymes...

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Detalles Bibliográficos
Autores principales: Kittilä, Tiia, Kittel, Claudia, Tailhades, Julien, Butz, Diane, Schoppet, Melanie, Büttner, Anita, Goode, Rob J. A., Schittenhelm, Ralf B., van Pee, Karl-Heinz, Süssmuth, Roderich D., Wohlleben, Wolfgang, Cryle, Max J., Stegmann, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620994/
https://www.ncbi.nlm.nih.gov/pubmed/28989629
http://dx.doi.org/10.1039/c7sc00460e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620994/
https://www.ncbi.nlm.nih.gov/pubmed/28989629
http://dx.doi.org/10.1039/c7sc00460e

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