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Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis
Halogenation plays a significant role in the activity of the glycopeptide antibiotics (GPAs), although up until now the timing and therefore exact substrate involved was unclear. Here, we present results combined from in vivo and in vitro studies that reveal the substrates for the halogenase enzymes...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620994/ https://www.ncbi.nlm.nih.gov/pubmed/28989629 http://dx.doi.org/10.1039/c7sc00460e |