Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry

Temporal control of siRNA activation is a major challenge for RNAi-based therapeutics. The majority of the reported siRNA delivery systems rely on environmental factors, such as differences in extracellular and intracellular redox potential, ATP concentration, or pH to activate an siRNA payload. How...

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Detalles Bibliográficos
Autores principales: Khan, Irfan, Seebald, Leah M., Robertson, Neil M., Yigit, Mehmet V., Royzen, Maksim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621156/
https://www.ncbi.nlm.nih.gov/pubmed/28989610
http://dx.doi.org/10.1039/c7sc01380a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621156/
https://www.ncbi.nlm.nih.gov/pubmed/28989610
http://dx.doi.org/10.1039/c7sc01380a

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