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Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry
Temporal control of siRNA activation is a major challenge for RNAi-based therapeutics. The majority of the reported siRNA delivery systems rely on environmental factors, such as differences in extracellular and intracellular redox potential, ATP concentration, or pH to activate an siRNA payload. How...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621156/ https://www.ncbi.nlm.nih.gov/pubmed/28989610 http://dx.doi.org/10.1039/c7sc01380a |