A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism

In a loss-of-viability screen of small molecules against methicillin resistant S. aureus (MRSA) USA300, we found a small molecule, designated DNAC-2, which has an MIC of 8 μg/ml. DNAC-2 is a quinolinol derivative that is bactericidal at 2X MIC. Macromolecular synthesis assays at 2X MIC of DNAC-2 inh...

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Detalles Bibliográficos
Autores principales: Nair, Dhanalakshmi R., Chen, Ji, Monteiro, João M., Josten, Michaele, Pinho, Mariana G., Sahl, Hans-Georg, Wu, Jimmy, Cheung, Ambrose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621627/
https://www.ncbi.nlm.nih.gov/pubmed/28698673
http://dx.doi.org/10.1038/ja.2017.79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621627/
https://www.ncbi.nlm.nih.gov/pubmed/28698673
http://dx.doi.org/10.1038/ja.2017.79

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