The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis

P53 protein is more frequently mutated in human tumours compared with the other proteins. While the majority of the p53 mutations, especially within its DNA-binding domain, lead to the loss of the wild-type function, there are accumulating data demonstrating that the p53 mutants gain tumour promotin...

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Detalles Bibliográficos
Autores principales: Makarov, Evgeny M., Shtam, Tatyana A., Kovalev, Roman A., Pantina, Rimma A., Varfolomeeva, Elena Yu, Filatov, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621691/
https://www.ncbi.nlm.nih.gov/pubmed/28961258
http://dx.doi.org/10.1371/journal.pone.0185126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621691/
https://www.ncbi.nlm.nih.gov/pubmed/28961258
http://dx.doi.org/10.1371/journal.pone.0185126

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