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The rare nonsense mutation in p53 triggers alternative splicing to produce a protein capable of inducing apoptosis
P53 protein is more frequently mutated in human tumours compared with the other proteins. While the majority of the p53 mutations, especially within its DNA-binding domain, lead to the loss of the wild-type function, there are accumulating data demonstrating that the p53 mutants gain tumour promotin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621691/ https://www.ncbi.nlm.nih.gov/pubmed/28961258 http://dx.doi.org/10.1371/journal.pone.0185126 |