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Scc2/Nipbl hops between chromosomal cohesin rings after loading

The cohesin complex mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping). It has been suggested that intra-chromosome loops are generated by extrusion of DNAs through the lumen of cohesin’s ring. Scc2 (Nipbl) stimulates cohesin’s ABC-like ATPase...

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Detalles Bibliográficos
Autores principales: Rhodes, James, Mazza, Davide, Nasmyth, Kim, Uphoff, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621834/
https://www.ncbi.nlm.nih.gov/pubmed/28914604
http://dx.doi.org/10.7554/eLife.30000