Understanding the differences of the ligand binding/unbinding pathways between phosphorylated and non-phosphorylated ARH1 using molecular dynamics simulations

ADP-ribosylhydrolases (ARH1, ARH2 and ARH3) are a family of enzymes to catalyze ADP-ribosylation, a reversible and covalent post-translational modification (PTM). There are four phosphorylated sites (Tyr-4, Tyr-19, Tyr-20, and Tyr-205) in ARH1. To explore the structural changes and functional impact...

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Detalles Bibliográficos
Autores principales: Zhu, Jingxuan, Lv, Yishuo, Han, Xiaosong, Xu, Dong, Han, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622063/
https://www.ncbi.nlm.nih.gov/pubmed/28963484
http://dx.doi.org/10.1038/s41598-017-12031-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622063/
https://www.ncbi.nlm.nih.gov/pubmed/28963484
http://dx.doi.org/10.1038/s41598-017-12031-0

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