Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model

The generation of T cells from pluripotent stem cells (PSCs) is attractive for investigating T cell development and validating genome editing strategies in vitro. X-linked severe combined immunodeficiency (X-SCID) is an immune disorder caused by mutations in the IL2RG gene and characterised by the a...

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Detalles Bibliográficos
Autores principales: Alzubi, Jamal, Pallant, Celeste, Mussolino, Claudio, Howe, Steven J., Thrasher, Adrian J., Cathomen, Toni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622068/
https://www.ncbi.nlm.nih.gov/pubmed/28963568
http://dx.doi.org/10.1038/s41598-017-12750-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622068/
https://www.ncbi.nlm.nih.gov/pubmed/28963568
http://dx.doi.org/10.1038/s41598-017-12750-4

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