AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG

Therapeutic IgG becomes unstable under various stresses in the manufacturing process. The resulting non-native IgG molecules tend to associate with each other and form aggregates. Because such aggregates not only decrease the pharmacological effect but also become a potential risk factor for immunog...

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Detalles Bibliográficos
Autores principales: Senga, Yukako, Imamura, Hiroshi, Miyafusa, Takamitsu, Watanabe, Hideki, Honda, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622108/
https://www.ncbi.nlm.nih.gov/pubmed/28963557
http://dx.doi.org/10.1038/s41598-017-12693-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622108/
https://www.ncbi.nlm.nih.gov/pubmed/28963557
http://dx.doi.org/10.1038/s41598-017-12693-w

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