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Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning

Hedgehog (Hh) signaling pathway and Cyclin E are key players in cell proliferation and organ development. Hyperactivation of hh and cyclin E has been linked to several types of cancer. However, coordination of the expression of hh and cyclin E was not well understood. Here we show that an evolutiona...

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Detalles Bibliográficos
Autores principales: Wang, Xian-Feng, Shen, Yang, Cheng, Qian, Fu, Chong-Lei, Zhou, Zi-Zhang, Hirose, Susumu, Liu, Qing-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622130/
https://www.ncbi.nlm.nih.gov/pubmed/28963499
http://dx.doi.org/10.1038/s41598-017-12766-w