Cargando…
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-rele...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622133/ https://www.ncbi.nlm.nih.gov/pubmed/28963545 http://dx.doi.org/10.1038/s41598-017-09635-x |
_version_ | 1783267850515906560 |
---|---|
author | Kano, Michiko Muratsubaki, Tomohiko Van Oudenhove, Lukas Morishita, Joe Yoshizawa, Makoto Kohno, Keiji Yagihashi, Mao Tanaka, Yukari Mugikura, Shunji Dupont, Patrick Ly, Huynh Giao Takase, Kei Kanazawa, Motoyori Fukudo, Shin |
author_facet | Kano, Michiko Muratsubaki, Tomohiko Van Oudenhove, Lukas Morishita, Joe Yoshizawa, Makoto Kohno, Keiji Yagihashi, Mao Tanaka, Yukari Mugikura, Shunji Dupont, Patrick Ly, Huynh Giao Takase, Kei Kanazawa, Motoyori Fukudo, Shin |
author_sort | Kano, Michiko |
collection | PubMed |
description | Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS. |
format | Online Article Text |
id | pubmed-5622133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56221332017-10-12 Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome Kano, Michiko Muratsubaki, Tomohiko Van Oudenhove, Lukas Morishita, Joe Yoshizawa, Makoto Kohno, Keiji Yagihashi, Mao Tanaka, Yukari Mugikura, Shunji Dupont, Patrick Ly, Huynh Giao Takase, Kei Kanazawa, Motoyori Fukudo, Shin Sci Rep Article Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS. Nature Publishing Group UK 2017-09-29 /pmc/articles/PMC5622133/ /pubmed/28963545 http://dx.doi.org/10.1038/s41598-017-09635-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kano, Michiko Muratsubaki, Tomohiko Van Oudenhove, Lukas Morishita, Joe Yoshizawa, Makoto Kohno, Keiji Yagihashi, Mao Tanaka, Yukari Mugikura, Shunji Dupont, Patrick Ly, Huynh Giao Takase, Kei Kanazawa, Motoyori Fukudo, Shin Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title | Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title_full | Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title_fullStr | Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title_full_unstemmed | Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title_short | Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome |
title_sort | altered brain and gut responses to corticotropin-releasing hormone (crh) in patients with irritable bowel syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622133/ https://www.ncbi.nlm.nih.gov/pubmed/28963545 http://dx.doi.org/10.1038/s41598-017-09635-x |
work_keys_str_mv | AT kanomichiko alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT muratsubakitomohiko alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT vanoudenhovelukas alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT morishitajoe alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT yoshizawamakoto alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT kohnokeiji alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT yagihashimao alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT tanakayukari alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT mugikurashunji alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT dupontpatrick alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT lyhuynhgiao alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT takasekei alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT kanazawamotoyori alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome AT fukudoshin alteredbrainandgutresponsestocorticotropinreleasinghormonecrhinpatientswithirritablebowelsyndrome |