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Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome

Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-rele...

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Autores principales: Kano, Michiko, Muratsubaki, Tomohiko, Van Oudenhove, Lukas, Morishita, Joe, Yoshizawa, Makoto, Kohno, Keiji, Yagihashi, Mao, Tanaka, Yukari, Mugikura, Shunji, Dupont, Patrick, Ly, Huynh Giao, Takase, Kei, Kanazawa, Motoyori, Fukudo, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622133/
https://www.ncbi.nlm.nih.gov/pubmed/28963545
http://dx.doi.org/10.1038/s41598-017-09635-x
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author Kano, Michiko
Muratsubaki, Tomohiko
Van Oudenhove, Lukas
Morishita, Joe
Yoshizawa, Makoto
Kohno, Keiji
Yagihashi, Mao
Tanaka, Yukari
Mugikura, Shunji
Dupont, Patrick
Ly, Huynh Giao
Takase, Kei
Kanazawa, Motoyori
Fukudo, Shin
author_facet Kano, Michiko
Muratsubaki, Tomohiko
Van Oudenhove, Lukas
Morishita, Joe
Yoshizawa, Makoto
Kohno, Keiji
Yagihashi, Mao
Tanaka, Yukari
Mugikura, Shunji
Dupont, Patrick
Ly, Huynh Giao
Takase, Kei
Kanazawa, Motoyori
Fukudo, Shin
author_sort Kano, Michiko
collection PubMed
description Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS.
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spelling pubmed-56221332017-10-12 Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome Kano, Michiko Muratsubaki, Tomohiko Van Oudenhove, Lukas Morishita, Joe Yoshizawa, Makoto Kohno, Keiji Yagihashi, Mao Tanaka, Yukari Mugikura, Shunji Dupont, Patrick Ly, Huynh Giao Takase, Kei Kanazawa, Motoyori Fukudo, Shin Sci Rep Article Stress is a known trigger of irritable bowel syndrome (IBS) and exacerbates its gastrointestinal symptoms. However, underlying the physiological mechanism remains unknown. Here, we investigated hypothalamic–pituitary–adrenal (HPA) axis, colonic motility, and autonomic responses to corticotropin-releasing hormone (CRH) administration as well as brain activity alterations in IBS. The study included 28 IBS patients and 34 age and sex-matched healthy control subjects. IBS patients demonstrated greater adrenocorticotropic hormone (ACTH) responses to CRH than control subjects. Male IBS patients had greater increases in colonic motility than male HCs after CRH. Female IBS patients showed altered sympathovagal balance and lower basal parasympathetic tone relative to female control subjects. Brain responses to rectal distention were measured in the same subjects using functional magnetic resonance imaging, and their associations with individual ACTH responses to CRH were tested. A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients. Impaired top-down inhibitory input from the pregenual ACC to the HPA axis may lead to altered neuroendocrine and gastrointestinal responses to CRH. Centrally acting treatments may dampen the stress induced physical symptoms in IBS. Nature Publishing Group UK 2017-09-29 /pmc/articles/PMC5622133/ /pubmed/28963545 http://dx.doi.org/10.1038/s41598-017-09635-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kano, Michiko
Muratsubaki, Tomohiko
Van Oudenhove, Lukas
Morishita, Joe
Yoshizawa, Makoto
Kohno, Keiji
Yagihashi, Mao
Tanaka, Yukari
Mugikura, Shunji
Dupont, Patrick
Ly, Huynh Giao
Takase, Kei
Kanazawa, Motoyori
Fukudo, Shin
Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title_full Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title_fullStr Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title_full_unstemmed Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title_short Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome
title_sort altered brain and gut responses to corticotropin-releasing hormone (crh) in patients with irritable bowel syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622133/
https://www.ncbi.nlm.nih.gov/pubmed/28963545
http://dx.doi.org/10.1038/s41598-017-09635-x
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