Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice

The type 2 vesicular monoamine transporter (VMAT2), by regulating the storage of monoamines transmitters into synaptic vesicles, has a protective role against their cytoplasmic toxicity. Increasing evidence suggests that impairment of VMAT2 neuroprotection contributes to the pathogenesis of Parkinso...

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Detalles Bibliográficos
Autores principales: Isingrini, Elsa, Guinaudie, Chloé, C Perret, Léa, Rainer, Quentin, Moquin, Luc, Gratton, Alain, Giros, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622135/
https://www.ncbi.nlm.nih.gov/pubmed/28963508
http://dx.doi.org/10.1038/s41598-017-12810-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622135/
https://www.ncbi.nlm.nih.gov/pubmed/28963508
http://dx.doi.org/10.1038/s41598-017-12810-9

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