SPA70 is a potent antagonist of human pregnane X receptor

Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SP...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622171/
https://www.ncbi.nlm.nih.gov/pubmed/28963450
http://dx.doi.org/10.1038/s41467-017-00780-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622171/
https://www.ncbi.nlm.nih.gov/pubmed/28963450
http://dx.doi.org/10.1038/s41467-017-00780-5

Ejemplares similares