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SPA70 is a potent antagonist of human pregnane X receptor

Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SP...

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Detalles Bibliográficos
Autores principales:	Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622171/ https://www.ncbi.nlm.nih.gov/pubmed/28963450 http://dx.doi.org/10.1038/s41467-017-00780-5

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