dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression

Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that could write epigenetic marks associated with a r...

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Detalles Bibliográficos
Autores principales: O’Geen, Henriette, Ren, Chonghua, Nicolet, Charles M., Perez, Andrew A., Halmai, Julian, Le, Victoria M., Mackay, Joel P., Farnham, Peggy J., Segal, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622328/
https://www.ncbi.nlm.nih.gov/pubmed/28973434
http://dx.doi.org/10.1093/nar/gkx578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622328/
https://www.ncbi.nlm.nih.gov/pubmed/28973434
http://dx.doi.org/10.1093/nar/gkx578

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