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dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression
Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that could write epigenetic marks associated with a r...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622328/ https://www.ncbi.nlm.nih.gov/pubmed/28973434 http://dx.doi.org/10.1093/nar/gkx578 |