Polμ tumor variants decrease the efficiency and accuracy of NHEJ

The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment of the broken ends, a complex task performed in human cells by two specialized DNA polymerases, Polλ and Polμ. It is now well established that Polμ...

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Detalles Bibliográficos
Autores principales: Sastre-Moreno, Guillermo, Pryor, John M., Díaz-Talavera, Alberto, Ruiz, José F., Ramsden, Dale A., Blanco, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622330/
https://www.ncbi.nlm.nih.gov/pubmed/28973441
http://dx.doi.org/10.1093/nar/gkx625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622330/
https://www.ncbi.nlm.nih.gov/pubmed/28973441
http://dx.doi.org/10.1093/nar/gkx625

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