LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage

LMO2 is a bridging factor within a DNA binding complex and is required for definitive haematopoiesis to occur. The developmental stage of the block in haematopoietic specification is not known. We show that Lmo2(−/−) mouse embryonic stem cells differentiated to Flk-1(+) haemangioblasts, but less eff...

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Detalles Bibliográficos
Autores principales: Stanulović, Vesna S., Cauchy, Pierre, Assi, Salam A., Hoogenkamp, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622341/
https://www.ncbi.nlm.nih.gov/pubmed/28973433
http://dx.doi.org/10.1093/nar/gkx573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622341/
https://www.ncbi.nlm.nih.gov/pubmed/28973433
http://dx.doi.org/10.1093/nar/gkx573

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