Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts

Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase failure by removing the abortive ligation product, i.e. the 5′-adenylate (5′-AMP) group, during DNA replication and repair. In the absence of APTX activity, blocked base excision repair (BER) intermediate...

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Detalles Bibliográficos
Autores principales: Çağlayan, Melike, Prasad, Rajendra, Krasich, Rachel, Longley, Matthew J., Kadoda, Kei, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Tano, Keizo, Copeland, William C., Wilson, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622373/
https://www.ncbi.nlm.nih.gov/pubmed/28973450
http://dx.doi.org/10.1093/nar/gkx654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622373/
https://www.ncbi.nlm.nih.gov/pubmed/28973450
http://dx.doi.org/10.1093/nar/gkx654

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