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Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis
Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes under...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622795/ https://www.ncbi.nlm.nih.gov/pubmed/28930162 http://dx.doi.org/10.3390/nu9091035 |