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Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea

Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to severe endothelial damage, can manifest in a diverse range of diseases. In complement-mediated atypical haemolytic uraemic syndrome (aHUS) a primary defect in complement, such as a mutation or autoantibody leadin...

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Detalles Bibliográficos
Autores principales: Brocklebank, Vicky, Kavanagh, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622895/
https://www.ncbi.nlm.nih.gov/pubmed/28980670
http://dx.doi.org/10.1093/ckj/sfx081