Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation

Aim of this work was to provide tamoxifen analogs with enhanced estrogen receptor (ER) binding affinity. Hence, several derivatives were prepared using an efficient triarylethylenes synthetic protocol. The novel compounds bioactivity was evaluated through the determination of their receptor binding...

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Detalles Bibliográficos
Autores principales: Kasiotis, Konstantinos M., Lambrinidis, George, Fokialakis, Nikolas, Tzanetou, Evangelia N., Mikros, Emmanuel, Haroutounian, Serkos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622936/
https://www.ncbi.nlm.nih.gov/pubmed/29018796
http://dx.doi.org/10.3389/fchem.2017.00071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622936/
https://www.ncbi.nlm.nih.gov/pubmed/29018796
http://dx.doi.org/10.3389/fchem.2017.00071

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