Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses

The rapid growth of tumors depends upon elevated levels of dNTPs, and while dNTP concentrations are tightly regulated in normal cells, this control is often lost in transformed cells. This feature of cancer cells has been used to advantage to develop oncolytic DNA viruses. DNA viruses employ many di...

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Detalles Bibliográficos
Autores principales: Irwin, Chad R., Hitt, Mary M., Evans, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622948/
https://www.ncbi.nlm.nih.gov/pubmed/29018771
http://dx.doi.org/10.3389/fonc.2017.00229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622948/
https://www.ncbi.nlm.nih.gov/pubmed/29018771
http://dx.doi.org/10.3389/fonc.2017.00229

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